Gravity versus pump-driven infusion in targeted radionuclide therapy: a model-based dosimetric evaluation of extravasation.

Fiche publication

Date publication

avril 2026

Journal

EJNMMI physics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr POROT Clémence , Dr SOMME François

Tous les auteurs :
Lienhardt O, Allegrini O, Poterszman N, Ritzenthaler F, Porot C, Mazzara C, Somme F, Salvadori J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41989671

Résumé

Intravenous administration of [Formula: see text]Lu-labeled radiopharmaceuticals (RPMs) such as PSMA and DOTATATE entails a risk of extravasation, potentially resulting in absorbed doses exceeding thresholds for deterministic tissue damage. Gravity-driven and pump-assisted infusion methods differ in dilution and flow dynamics, which directly affect the extravasated dose. This study aimed to extend and validate an analytical model for quantitative comparison of extravasation-related dosimetric risks between both strategies and to inform clinical protocol optimization.