Fiche publication
Date publication
octobre 2014
Journal
BMC bioinformatics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GAQUEREL Emmanuel
Tous les auteurs :
Walter W, Striberny B, Gaquerel E, Baldwin IT, Kim SG, Heiland I
Lien Pubmed
Résumé
As time series experiments in higher eukaryotes usually obtain data from different individuals collected at the different time points, a time series sample itself is not equivalent to a true biological replicate but is, rather, a combination of several biological replicates. The analysis of expression data derived from a time series sample is therefore often performed with a low number of replicates due to budget limitations or limitations in sample availability. In addition, most algorithms developed to identify specific patterns in time series dataset do not consider biological variation in samples collected at the same conditions.
Mots clés
Algorithms, Circadian Clocks, genetics, Gene Expression Profiling, methods, Kinetics, Reproducibility of Results
Référence
BMC Bioinformatics. 2014 10 25;15(1):352
