Fiche publication
Date publication
janvier 2019
Journal
Molecules (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SCHALLER Hubert
Tous les auteurs :
Darnet S, Schaller H
Lien Pubmed
Résumé
4,4-Dimethylsterols and 4-methylsterols are sterol biosynthetic intermediates (C4-SBIs) acting as precursors of cholesterol, ergosterol, and phytosterols. Their accumulation caused by genetic lesions or biochemical inhibition causes severe cellular and developmental phenotypes in all organisms. Functional evidence supports their role as meiosis activators or as signaling molecules in mammals or plants. Oxygenated C4-SBIs like 4-carboxysterols act in major biological processes like auxin signaling in plants and immune system development in mammals. It is the purpose of this article to point out important milestones and significant advances in the understanding of the biogenesis and biological activities of C4-SBIs.
Mots clés
4-methylsterol, C4-demethylation complex (C4DMC), development, genetic disease, hormone, steroid, sterol
Référence
Molecules. 2019 01 27;24(3):
