Fiche publication
Date publication
juin 2019
Journal
Marine drugs
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SCHALLER Hubert
Tous les auteurs :
Claereboudt EJS, Caulier G, Decroo C, Colson E, Gerbaux P, Claereboudt MR, Schaller H, Flammang P, Deleu M, Eeckhaut I
Lien Pubmed
Résumé
Echinoderms form a remarkable phylum of marine invertebrates that present specific chemical signatures unique in the animal kingdom. It is particularly the case for essential triterpenoids that evolved separately in each of the five echinoderm classes. Indeed, while most animals have Δ-sterols, sea cucumbers (Holothuroidea) and sea stars (Asteroidea) also possess Δ and Δ-sterols, a characteristic not shared with brittle stars (Ophiuroidea), sea urchins (Echinoidea), and crinoids (Crinoidea). These particular Δ and Δ sterols emerged as a self-protection against membranolytic saponins that only sea cucumbers and sea stars produce as a defense mechanism. The diversity of saponins is large; several hundred molecules have been described in the two classes of these saponins (i.e., triterpenoid or steroid saponins). This review aims to highlight the diversity of triterpenoids in echinoderms by focusing on sterols and triterpenoid glycosides, but more importantly to provide an updated view of the biosynthesis of these molecules in echinoderms.
Mots clés
echinoderms, saponins, sterols, triterpenoids
Référence
Mar Drugs. 2019 06 13;17(6):
