Fiche publication
Date publication
mars 2020
Journal
Molecules (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SCHALLER Hubert
Tous les auteurs :
Darnet S, Martin LBB, Mercier P, Bracher F, Geoffroy P, Schaller H
Lien Pubmed
Résumé
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.
Mots clés
SBI, cholesterol, fungicide, selective herbicide, sitosterol, steroidogenesis inhibitor
Référence
Molecules. 2020 03 2;25(5):
