New insights into prostate cancer progression: A focus on vitamin D signaling.

Date publication

avril 2026

Journal

The Journal of steroid biochemistry and molecular biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LAVERNY Gilles

Tous les auteurs :
Friedrich V, Laverny G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41962639

Résumé

Prostate cancer (PCa) is one of the most frequent cancer in men of western society. Whereas the therapeutic options for localized PCa are efficient, those for advanced forms lead to resistance and are of a poor outcome. Thus, it is of utmost importance to understand the mechanisms underlying PCa progression to identify biomarkers predicting tumor evolution and novel therapeutic options. This review summarizes the current knowledge on PCa progression, treatments and preclinical approaches, with a specific emphasis on the role of vitamin D signaling.

Mots clés

Castration resistance, Chemoresistance, Genetically engineered mouse models, Patient derived organoids, Prostate cancer, Vitamin D, Vitamin D receptor

Référence

J Steroid Biochem Mol Biol. 2026 04 8;261:107019