Improving CTV delineation after preoperative systemic therapy in breast cancer using deformable PET/CT registration.

Fiche publication

Date publication

mars 2026

Journal

Breast (Edinburgh, Scotland)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MERROUCHE Yacine , Pr PAPATHANASSIOU Dimitri , Dr JOUANNAUD Christelle , Dr HOTTON Judicaël

Tous les auteurs :
Kemmeugne J, Gallay L, Morland D, Hotton J, Jouannaud C, Merrouche Y, Papathanassiou D, Reyal F, Ndéo Sene M, Torielli P, Vignot S, Guilbert P, Beddok A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41926859

Résumé

Delineating the CTV in postoperative breast radiation therapy (RT) may be challenging after preoperative systemic therapy (PST), due to treatment-induced anatomical changes and the potential discordance between the postoperative surgical cavity, as identified by surgical clips, and the spatial extent of the pretreatment tumor. The objective of this study was to assess whether [F]-FDG PET/CT (PET/CT)-guided delineation using deformable image registration (DIR) improves inter-observer reproducibility compared to conventional strategies relying primarily on surgical clips and anatomical landmarks.