Foslip-Mediated Photodynamic Treatment Reprograms Macrophages Phenotype in Tri-Culture Head and Neck Cancer Spheroids.

Fiche publication

Date publication

mars 2026

Journal

International journal of nanomedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina , Pr DOLIVET Gilles , Dr MASTRONICOLA Romina

Tous les auteurs :
Francois A, Dirheimer L, Mastronicola R, Dolivet G, Bezdetnaya L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41873361

Résumé

The tumor microenvironment (TME) composition is among the critical events leading to the poor prognosis of head and neck cancers. TME includes immune cells, tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAF), and other non-cancerous cells, which contribute to therapeutic outcome. The heterogeneity of the TME offers a multitude of potential targets for photodynamic therapy (PDT). Advanced 3D models that closely mimic the microenvironment are a promising tool to study tumor-stroma interactions, TAM plasticity and their impact on Foslip-PDT outcome.