Fiche publication
Date publication
août 2014
Journal
Current opinion in microbiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr IMLER Jean-Luc
Tous les auteurs :
Lamiable O, Imler JL
Lien Pubmed
Résumé
Immunity to viral infections in the model organism Drosophila melanogaster involves both RNA interference and additional induced responses. The latter include not only cellular mechanisms such as programmed cell death and autophagy, but also the induction of a large set of genes, some of which contribute to the control of viral replication and resistance to infection. This induced response to infection is complex and involves both virus-specific and cell-type specific mechanisms. We review here recent developments, from the sensing of viral infection to the induction of signaling pathways and production of antiviral effector molecules. Our current understanding, although still partial, validates the Drosophila model of antiviral induced immunity for insect pests and disease vectors, as well as for mammals.
Mots clés
Animals, Drosophila melanogaster, immunology, Gene Expression Regulation, Host-Pathogen Interactions, Immunity, Innate, RNA Viruses, immunology, Signal Transduction
Référence
Curr. Opin. Microbiol.. 2014 Aug;20:62-8
