Club cell secretory protein (CCSP) serum concentration is a prognostic factor after surgical resection of localized non-small cell lung cancer in patients in the IFCT-0302 trial.

Fiche publication

Date publication

février 2026

Journal

Lung cancer (Amsterdam, Netherlands)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DEBIEUVRE Didier , Dr FOUCHER Pascal , Pr WESTEEL Virginie

Tous les auteurs :
Brosseau S, Etienne H, Peoc'h K, Langlais A, Blanché H, Foucher P, Barlesi F, Domas J, Girard P, Scherpereel A, Dumont P, Derollez M, Quoix E, Debieuvre D, Deleuze JF, Leçon-Malas V, Zalcman G, Westeel V, Mordant P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41793820

Résumé

No specific follow-up strategy has shown to improve overall survival (OS) after surgical resection of non-small cell lung cancer (NSCLC). Club cell secretory protein (CCSP) is produced by bronchiolar club cells and shows promise as a survival biomarker as its concentration depends on degree of lung inflammation. Our objective was to evaluate prognostic impact of postoperative serum CCSP concentration on OS after resection of stage I to IIIA NSCLC in a post hoc ancillary analysis of the IFCT-0302 trial.