Fiche publication
Date publication
février 2026
Journal
Cell reports. Medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen
,
Dr QUERE Ronan
,
Dr BRUCHARD Mélanie
,
Dr BELLAYE Pierre-Simon
Tous les auteurs :
Georgievski A, Blanc N, Bruchard M, Pignol C, Bellaye PS, Garrido C, Quéré R
Lien Pubmed
Résumé
We develop valrubicin-loaded immunoliposomes (Val-ILs), a nanoparticle-based therapy designed to target immunosuppressive cells that promote immune evasion in cancer. In vivo screening following intravenous administration in mice identifies nine relevant surface targets, including known immunoregulatory markers (LAG-3 and VEGFR2) and not-well-characterized candidates (CD11b, CD64, TIM1, CD200R3, CD204, CD49b, and SIGLEC-F). Within the tumor microenvironment, Val-ILs treatment broadly reduces the expression of these antigens on immunosuppressive populations, including tumor-associated macrophages, myeloid-derived suppressor cells, regulatory T cells, and T helper 17 cells, as well as on innate anti-tumor cells such as tumor-associated natural killer cells and tumor-infiltrating dendritic cells. Across four murine cancer models, two responsive (T and B lymphomas) and two resistant (orthotopic breast and lung cancers), Val-ILs decorated with antibodies against the nine targets significantly enhance anti-PD-1 efficacy. This combination boosts the presence of CD4 and CD8 tumor-infiltrating lymphocytes, reprograms tumor-associated macrophages toward an M1-like phenotype, and improves tumor control and metastasis reduction.
Mots clés
enhance anti-tumor immunity in resistant cancer models, immunosuppressive cells, murine cancer models, nanoparticle-based therapy, reduced metastasis, tumor regression, valrubicin-loaded immunoliposomes
Référence
Cell Rep Med. 2026 02 27;:102632
