Characterisation of early-onset pancreatic adenocarcinoma molecular profile compared to average-onset pancreatic adenocarcinoma (CARAPAC): A systematic review and a meta-analysis.

Date publication

mars 2026

Journal

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BOUCHE Olivier , Dr OUDART Jean-Baptiste

Tous les auteurs :
Brugel M, Riviere V, Hubert A, Langanay L, Bouche O, Genin M, Gauthier V, Oudart JB

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41791948

Résumé

Early-onset pancreatic adenocarcinoma (EOPA), defined as the diagnosis of pancreatic adenocarcinoma before the age of 50, is increasingly reported and may differ molecularly from average-onset pancreatic adenocarcinoma (AOPA). Understanding these differences is essential for precision medicine in this poor-prognosis malignancy.

Mots clés

Early-onset pancreatic cancer, Human, KRAS protein, Molecular, Pancreatic Neoplasms, Somatic mutations, Targeted therapy

Référence

Pancreatology. 2026 03 3;: