Fiche publication
Date publication
mars 2025
Journal
ESMO gastrointestinal oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEPAGE Côme
Tous les auteurs :
Gandini A, Gallois C, Blons H, Mulot C, Agueeff N, Lepage C, Guimbaud R, Mineur L, Desramé J, Chibaudel B, de Reyniès A, André T, Laurent-Puig P, Taieb J
Lien Pubmed
Résumé
Despite decreasing colon cancer (CC) incidence worldwide, an inverse trend is being registered since the late 1990s in people <50 years old, possibly due to an increasing exposure to lifestyle-related risk factors/exposome. Early-onset CC (EOCC) typically manifests in more advanced stages and may harbor a distinct genetic profile. However, its prognosis remains controversial, and disease stratification through gene expression-based subtyping could potentially provide insight.
Mots clés
CMS, colorectal cancer, early-onset colorectal cancer, genetic profile, transcriptomic profile
Référence
ESMO Gastrointest Oncol. 2025 03;7:100106
