The impact of allogeneic hematopoietic stem cell transplantation on pulmonary complications in adults with inborn errors of immunity.

Date publication

septembre 2025

Journal

The Journal of allergy and clinical immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MARCAIS Ambroise

Tous les auteurs :
Le Gal A, Marçais A, Goyard C, Brun AL, Cheminant M, Mahlaoui N, Givel C, Tcherakian C, Chabrol A, Wallyn F, Magro L, Sicre de Fontbrune F, Peffault de la Tour R, Tazi A, Benattia A, Valter R, Devillier P, Couderc LJ, Suarez F, Catherinot E, Salvator H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40378970

Résumé

Pulmonary involvement (repeated lung infections, lung parenchymal inflammation, scarring, and malignancies) is frequent in patients with inborn errors of immunity (IEIs) and accounts for a significant proportion of the disease burden. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure most severe IEIs. The indications for allo-HSCT have recently been extended to adults.

Mots clés

Inborn errors of immunity, hematopoietic stem cell transplantation, primary immunodeficiency, respiratory infections

Référence

J Allergy Clin Immunol. 2025 09;156(3):825-834