A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study.

Date publication

novembre 2025

Journal

The Lancet. Microbe

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MARCAIS Ambroise

Tous les auteurs :
Karpe SD, Artesi M, Wayet J, Durkin K, Hahaut V, Uchimaru K, Makiyama J, Iwanaga M, Utsunomiya A, Kolijn PM, Langerak AW, Burny A, Marçais A, Hermine O, Watanabe T, Georges M, Van den Broeke A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41213277

Résumé

Adult T-cell leukaemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that occurs in approximately 2-7% of individuals with human T-lymphotropic virus type 1 (HTLV-1), after decades of asymptomatic infection. To address the urgent need for predictive biomarkers to identify asymptomatic carriers of HTLV-1 at high risk of progression to ATL, we aimed to evaluate viral clonality sequencing as a potential tool for risk stratification.

Mots clés

Humans, Human T-lymphotropic virus 1, genetics, Leukemia-Lymphoma, Adult T-Cell, virology, Longitudinal Studies, Retrospective Studies, Male, Japan, epidemiology, Female, Viral Load, Disease Progression, Middle Aged, Adult, HTLV-I Infections, virology, Carrier State, virology, Proviruses, genetics, Aged, DNA, Viral, genetics

Référence

Lancet Microbe. 2025 11;6(11):101198