Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma.

Fiche publication

Date publication

janvier 2026

Journal

Journal for immunotherapy of cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr AMARAL Teresa Maria

Tous les auteurs :
Herold N, Bochem J, Leyens J, Wingerter S, Forchhammer S, Spreuer J, Deseke M, Yurttas C, Nocerino P, Antunes Dos Reis R, Amaral T, Wagner NB, Thiel K, Soffel D, Bieber K, Terheyden P, Wesch D, Oberg HH, Sebens S, Claassen M, Königsrainer A, Garbe C, Pawelec G, Meier F, Löffler MW, Weide B, Prinz I, Ravens S, Kordasti S, Eigentler T, Wistuba-Hamprecht K

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41558811

Résumé

Although most studies of anticancer T-cell immunity focus on αβ T cells, γδ T cells are attracting increasing attention due to their involvement in antitumor immune responses in various cancer entities, including melanoma. While immune checkpoint blockade (ICB) using the antagonistic programmed cell death protein 1 (PD-1) antibodies nivolumab and pembrolizumab significantly improved the survival of patients with melanoma with distant metastasis, prognosis remains poor. PD-1 is not only expressed by αβ T cells but also by γδ T cells, making this numerically minor population of unconventional T cells, whose role in melanoma is still elusive, a target of ICB.