Fiche publication
Date publication
mars 2026
Journal
Neurology(R) neuroimmunology & neuroinflammation
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme
Tous les auteurs :
Rommer PS, Jiang W, Nolte JP, Mikami T, De Seze J, Sánchez P, Harel A, Alkabie S, Kaneko K, Bilodeau PA, Misu T, Kremer L, Bigaut K, Leypoldt F, Aktas O, Ringelstein M, Siffrin V, Zhang LJ, Cong H, Lowe M, Barreras P, Chen H, Piquet AL, Sotirchos ES, Kammeyer R, Zook J, Bennett JL, Berger T, Fujihara K, Levy M, Shi FD, Paul F
Lien Pubmed
Résumé
Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune disease mainly driven by aquaporin-4 antibodies (AQP4-IgG). During an attack, AQP4-IgG activates the complement system, leading to astrocyte destruction, inflammation, neuronal damage, and thus devastating and often irreversible neurologic deficits. Terminal complement inhibitors such as eculizumab and ravulizumab effectively prevent relapses, yet their therapeutic potential in stopping ongoing complement-mediated injury during acute attacks remains insufficiently explored.
Mots clés
Humans, Neuromyelitis Optica, drug therapy, Female, Middle Aged, Male, Antibodies, Monoclonal, Humanized, pharmacology, Adult, Retrospective Studies, Complement Inactivating Agents, pharmacology, Aged, Aquaporin 4, immunology
Référence
Neurol Neuroimmunol Neuroinflamm. 2026 03;13(2):e200548
