Minimal immune response after transplantation of a cryopreserved human amniotic membrane on the ocular surface.

Fiche publication

Date publication

avril 2026

Journal

Materials today. Bio

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GINDRAUX Florelle

Tous les auteurs :
Baudey JB, Solecki L, Picard C, Mathéaud B, Jamain P, Jollet I, Hubert L, Coaquette A, Desanlis A, Lafarge X, Pedini P, Gindraux F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41640604

Résumé

Human amniotic membrane (hAM) is considered to have low immunogenicity since Akle et al. reported no anti-HLA antibodies (Abs) in four volunteers after subcutaneous grafting of fresh hAM in 1981. But the sensitivity of the detection methods has significantly improved since then. Furthermore, hAM graft is a massive local input of allogenic HLA-G whose potential immunogenicity has never been assessed. The objective of this study was to look for the presence of anti-HLA class I, II, and anti HLA-G Abs at 1 and 3 months after hAM transplantation on the ocular surface.