Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010.

Date publication

janvier 2026

Journal

British journal of pharmacology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GOUMON Yannick

Tous les auteurs :
Inquimbert P, Fitterer C, Hugel S, Jesic M, Goumon Y, Andry V, Schneider S, Daubeuf F, Faouzi A, Doridot S, Majumdar S, Bihel F, Schmitt M, Massotte D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41492212

Résumé

Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ-δ opioid receptor heteromers. In this study, we compared its pharmacological profile and antinociceptive properties in naive and neuropathic conditions to those of the μ-δ biased agonist CYM51010 and the μ opioid agonist morphine.

Mots clés

G protein‐coupled receptor, heteromer, internalization, neuropathic pain, opioid receptor, respiratory depression, sex difference, signalling

Référence

Br J Pharmacol. 2026 01 6;: