Fiche publication
Date publication
janvier 2026
Journal
iScience
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
Bonazzi E, Hao F, Patterson AD, Peyrin-Biroulet L, Jensen BAH, Chassaing B
Lien Pubmed
Résumé
The gastrointestinal tract hosts a diverse microbial community, named the intestinal microbiota, which plays a vital role in gut health. Host defense peptides (HDPs), such as defensins, help regulate interactions between the host and its microbiota. Dysfunction in HDPs expression has been associated with a greater risk of inflammatory bowel diseases (IBDs), while some HDPs may positively shape the gut environment. Human alpha defensin 5 (HD5) can be cleaved by intestinal enzymes into bioactive fragments such as HD5. In this study, we screened various HDPs (LL-37, hBD2, HD5, and HD5) for their modulatory effects on healthy human microbiotas and found distinct, donor-specific effects, with HD5 showing the strongest functional impact. Testing HD5 in a mouse colitis model revealed potent and microbiota-dependent protection against DSS-induced inflammation, partly through the beneficial of mucus-microbiota interactions. These findings highlight the potential of HDPs, especially HD5, in modulating gut microbiota and treating intestinal inflammation.
Mots clés
Gastroenterology, Immunology, Microbiology
Référence
iScience. 2026 01 16;29(1):114310
