Fiche publication
Date publication
janvier 2026
Journal
ACS applied bio materials
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRANCIUS Grégory
Tous les auteurs :
Siniscalco D, Quilès F, Say K, Airoudj A, Roucoules V, Renard A, Mallet M, Francius G
Lien Pubmed
Résumé
Ulvan, a sulfated marine polysaccharide, holds promise for antiadhesive and antimicrobial surface coatings. We engineered two ulvan-based coating series by covalently grafting ulvan onto poly(allylamine)-modified substrates using EDC/s-NHS or BDDE cross-linking chemistries. Surface analyses confirmed tunable morphology and composition with coating thickness and ulvan density saturated at defined cross-linker thresholds. Adhesion assays with and revealed significantly reduced colonization on all ulvan coatings versus uncoated controls. adhesion decreased exponentially with ulvan density with nanogel-like coatings also inducing membrane damage. exhibited weaker transient responses, possibly due to structural resistance. Correlating biological activity with surface chemistry established ulvan content as a key predictor of performance. These coatings offer short-term protection against microbial colonization, particularly effective during the critical early adhesion phase, and provide a chemically tunable platform for anti-infective surfaces in applications such as catheters, wound dressings, and food-contact materials. This work lays the groundwork for designing glycosylated interfaces in biomedical and environmental applications where early stage biofilm prevention is critical.
Mots clés
Ulvan, X-ray photoelectron spectroscopy, antiadhesion, antibiofilm, atomic force microscopy, infrared spectroscopy, surface functionalization
Référence
ACS Appl Bio Mater. 2026 01 20;:
