Fiche publication
Date publication
décembre 2025
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
,
Dr BERQUAND Alexandre
Tous les auteurs :
Cadoret L, Okwieka A, Berquand A, Pietrement C, Gillery P, Jaisson S
Lien Pubmed
Résumé
Vascular smooth muscle cells (VSMCs) are characterized by a considerable plasticity. Their phenotypic switch (from contractile to synthetic) plays a crucial role in the atherosclerotic process, explaining that numerous studies focus on this phenotypic transition. Thus, it is essential to use VSMCs that have been finely phenotyped for experimental purposes. The use of MOVAS cell line is suitable because, unlike primary cells, it is believed that these cells retain their phenotype and avoid cell senescence in culture. This study aimed to assess the phenotype of MOVAS cells over culture passages to ensure that they retained a contractile phenotype, before using them for further investigations.
Mots clés
Animals, Muscle, Smooth, Vascular, cytology, Mice, Kruppel-Like Factor 4, Phenotype, Cell Line, Aorta, cytology, Cell Movement, Myocytes, Smooth Muscle, cytology, Muscle Contraction, Cell Adhesion
Référence
PLoS One. 2025 12 19;20(12):e0339118
