Fiche publication
Date publication
décembre 2025
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Mme DEMAIS Valérie
,
Dr GOUMON Yannick
,
Dr KREMER Mélanie
Tous les auteurs :
Baudon A, Grelot V, Wang KY, Althammer F, Denis C, Riché-Piotaix P, Ali AS, Yan Y, Castillo Díaz F, Piacentini F, Clauss Creusot E, Hovhannisyan V, Schubert T, Kleinwaechter AC, Eisemann EM, Muhammad JA, Helen J, Lakomy T, Krabichler Q, Breton R, Andry V, Carrillo-de Sauvage MA, Demais V, Cès A, Franke F, Schommer F, Kremer M, Di Benedetto B, Goumon Y, Schaaf CP, Grinevich V, Rouach N, Darbon P, Neumann ID, Adamantidis A, Busnelli M, Benhaim L, Krijgsveld J, Pfrieger FW, Charlet A
Lien Pubmed
Résumé
Anticipated reactions to stressful situations are vital for the survival and well-being of organisms, and abnormal reactions results in stress-related disorders. The neuropeptide oxytocin is a key modulator ensuring well-adapted stress responses. Oxytocin acts on both neurons and astrocytes, but the molecular and cellular mechanisms mediating stress response remain poorly understood. Here, we focus on the amygdala, a crucial hub that integrates and processes sensory information through oxytocin-dependent mechanisms. Using an acute stress paradigm in mice, genetic and pharmacological manipulations combined with proteomic, morphological, electrophysiological and behavioral approaches, we reveal that oxytocinergic modulation of the freezing response to stress is mediated by transient Gαi-dependent retraction of astrocytic processes, followed by enhanced neuronal sensitivity to extracellular potassium in the amygdala. Our findings elucidate a pivotal role for astrocytes morphology-dependent modulation of brain circuits that is required for proper anticipated behavioral response to stressful situations.
Référence
Nat Commun. 2025 12 29;:
