Influence of oxygen conditioning on the production of secretome by human mesenchymal stromal cells in stirred bioreactors.

Fiche publication

Date publication

novembre 2025

Journal

Cytotherapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr OLMOS Eric

Tous les auteurs :
Audoux K, Madec E, Branchu J, Olmos E, Schiavi-Tritz J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41371058

Résumé

Human mesenchymal stromal cells derived from Wharton Jelly (hWJ-MSCs) release a broad range of bioactive components, collectively known as the secretome. This secretome includes growth factors, cytokines and extracellular vesicles (EVs). The secretome has significant therapeutic potential, such as modulating inflammation, promoting tissue repair and inhibiting tumor proliferation. The cellular microenvironment, particularly the oxygen level, plays a critical role in influencing the quantity and quality of the secretome.