Large B-cell lymphoma: The LYSA pragmatic guidelines.

Fiche publication

Date publication

décembre 2025

Journal

European journal of cancer (Oxford, England : 1990)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARTIN Laurent , Pr FORNECKER Luc-Matthieu

Tous les auteurs :
Sesques P, Manson G, Dubois S, Gros FX, Brisou G, Sarkozy C, Bernard S, Bourbon E, Fornecker LM, Durot E, Martin L, Chassagne-Clément C, Llamas Gutierrez F, Syrykh C, Delfau-Larue MH, Kanoun S, Vercellino L, Bodet-Milin C, Bahri H, Zhang Yin J, Dony A, Lebras L, Ochmann M, Baron M, Monjanel H, Le Calloch R, Claves F, Kirova Y, Gisselbrecht C, Guidez S, Bossard JB, Di Blasi R, Delette C, Fouillet L, Rhomdani M, Belhadj M, Crochet G, Amorim S, Safa F, Drieu La Rochelle L, Abraham J, Thieblemont C, Jardin F, Noel R, Bailly S, Renaud L, Guillermin Y, Delapierre B, Choquet S, Roulin L, Lamure S, Galicier L, Al Tabaa Y, Soussain C, Guièze R, Houot R, Tessoulin B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41352004

Résumé

The management of large B-cell lymphomas (LBCL) has undergone major changes over the last 5 years. These changes reflect the availability of new therapies (immunotherapies, cell therapies, targeted molecules), but also a better compartmentalization of the entities and their specific clinical characteristics. Numerous first-, second- and third-line therapeutic strategies are available, and each practitioner is committed to selecting the treatment that offers the best balance between efficacy and toxicity. Advances in the understanding of LBCL biology, coupled with improvements in diagnostic and monitoring tools and therapeutic approaches, have significantly enhanced patient outcomes in recent years. In this article, we present a set of pragmatic guidelines developed by the LYSA (Lymphoma Study Association) for the management of LBCL. These guidelines address key aspects of diagnosis, staging, response evaluation, and treatment, integrating the latest evidence from clinical trials, expert consensus, and real-world practice. They aim to provide clinicians with a clear, practical framework to optimize care for patients with LBCL, ensuring that the best available evidence is translated into clinical practice.