Incubation of social deficit during morphine abstinence in male mice using a novel unbiased and automatized method.

Fiche publication

Date publication

octobre 2025

Journal

Frontiers in behavioral neuroscience

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DARCQ Emmanuel

Tous les auteurs :
Mathis VP, Giua G, Torquet N, Mittelhaeuser C, Bour R, Kieffer BL, Riet F, Darcq E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41234535

Résumé

Opioid use disorder (OUD) is a chronic relapsing condition caused by prolonged opioid exposure, which triggers adaptive changes in the brain. These changes make it challenging to control or abstain from consuming, and significantly increase the risk of relapse. While the physical symptoms of withdrawal typically resolve within a few days, extended abstinence is frequently accompanied by the progressive development of emotional disturbances. Additionally, abstinent individuals often report social disengagement, or even social isolation that worsen the condition and participates in the development of comorbidities. These disturbances are similarly observed in murine models of opioid abstinence.