Nuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx.

Fiche publication

Date publication

novembre 2025

Journal

Translational oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr JUNG Alain , Mme KOBLER Amandine , Dr BURGY Mickaël

Tous les auteurs :
Philouze P, Benzerdjeb N, Malésys C, Wozny AS, Soumboundou M, Kobler A, Jung AC, Burgy M, Céruse P, Alphonse G, Rodriguez-Lafrasse C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41187427

Résumé

Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor that regulates the expression of cytoprotective genes, and peroxiredoxin 6 is one of the proteins regulated by NRF2. Both are potentially involved in the resistance to treatments as they play a central role in the response to oxidative stress.