Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa.

Fiche publication

Date publication

novembre 2025

Journal

Journal of the American Heart Association

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie

Tous les auteurs :
Trimaille A, Hmadeh S, Kikuchi S, Mroueh A, Carmona A, Marchandot B, Beras F, Truong DP, Vu MC, Granier A, Jesel L, Ohlmann P, Sattler L, Schini-Kerth V, Morel O

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41294140

Résumé

The role of plasma and its components in the progression of aortic stenosis (AS) remains insufficiently investigated. This study aimed to assess whether plasma from patients with AS induces oxidative stress and contributes to valvular endothelial cells (VECs) dysfunction.