A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling.

Date publication

août 2014

Journal

Oncotarget

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BOIDOT Romain

Tous les auteurs :
Boidot R, Branders S, Helleputte T, Rubio LI, Dupont P, Feron O

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25216520

Résumé

Temporal and local fluctuations in O2 in tumors require adaptive mechanisms to support cancer cell survival and proliferation. The transcriptome associated with cycling hypoxia (CycHyp) could thus represent a prognostic biomarker of cancer progression.

Mots clés

Breast Neoplasms, genetics, Cell Hypoxia, genetics, Cell Proliferation, genetics, Cell Survival, genetics, Female, Gene Expression Profiling, Humans, Prognosis, RNA, Messenger, genetics

Référence

Oncotarget. 2014 Aug;5(16):6947-63