Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.

Date publication

août 2014

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand

Tous les auteurs :
Ruocco MG, Chaouat G, Florez L, Bensussan A, Klatzmann D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25191324

Résumé

In this review, we first revisit the original concept of "suppressor T-cells" in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of "regulatory T-cells" (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal-fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.

Mots clés

NK cells, Treg, cancer tolerance, evolution of the immune system, suppressor T-cells

Référence

Front Immunol. 2014 08 21;5:389