Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions.

Date publication

août 2014

Journal

Nanoscale

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MENARD-MOYON Cécilia , Dr BIANCO Alberto

Tous les auteurs :
Crescio C, Orecchioni M, Ménard-Moyon C, Sgarrella F, Pippia P, Manetti R, Bianco A, Delogu LG

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25029354

Résumé

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

Mots clés

Cells, Cultured, Cytokines, analysis, Humans, Immunologic Factors, chemistry, Monocytes, chemistry, Nanotubes, Carbon, chemistry, T-Lymphocytes, chemistry, Weightlessness

Référence

Nanoscale. 2014 Aug 21;6(16):9599-603