Insight into the Roles of Albumin-Alone and in Combination with Either Voriconazole or Antimicrobial Peptides Derived from Chromogranin A-In the Growth of Different Microbial Species.

Fiche publication

Date publication

septembre 2025

Journal

Antibiotics (Basel, Switzerland)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe , Pr SCHAAF Pierre

Tous les auteurs :
Schneider F, Hellé S, Strub JM, von Hunolstein FX, Schaaf P, Lavalle P, Scavello F, Metz-Boutigue MH

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41148665

Résumé

Whether therapeutic albumin (ThHSA) can serve as a defense tool in species (spp.) infections is still a matter of debate, although many physicians are in the habit of infusing ThHSA to restore the physiological concentration of endogenous human serum albumin (HSA). Given the need for innovative anti-Candida strategies, we assessed the role of ThHSA alone or in combination with voriconazole (VCZ) in combating spp. growth and the role of bovine serum albumin (BSA)-used as a substitute for HSA-with two endogenous bovine antimicrobial peptides in combating and other microbes.