Fiche publication
Date publication
octobre 2025
Journal
BMC biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PIEUCHOT Laurent
Tous les auteurs :
Arnold C, Tahmaz I, Chapon ML, Maayouf H, Luchnikov V, Milan JL, Borghi F, Pieuchot L
Lien Pubmed
Résumé
Curvature is a ubiquitous feature in biology, shaping structures at every scale and playing diverse roles in processes ranging from membrane dynamics to tissue organization. In this review, we first introduce briefly the fundamental concepts and mathematical principles of curvature. The second section explores how membrane curvature is perceived by molecular sensors and integrated into cellular responses. The third section examines the effects of curvature on cellular processes and behaviors at the cell-scale, providing a detailed discussion of the underlying mechanisms. Finally, we offer insights into emerging perspectives and highlight the future challenges in unraveling the multifaceted roles of curvature in biology.
Mots clés
Cell migration, Curvature, Curvotaxis, Mechanosensing, Substrate topography
Référence
BMC Biol. 2025 10 6;23(1):296
