Total-body irradiation-based versus chemotherapy alone as myeloablative conditioning regimen prior to hematopoietic allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia: a multi-institutional study from the Francophone Society

Fiche publication

Date publication

octobre 2025

Journal

International journal of radiation oncology, biology, physics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BILGER Karin

Tous les auteurs :
Belkacemi Y, Debbi K, Hanh To N, de La Tour RP, Quero L, Balsat M, Martel-Lafay I, Beauvais D, Mirabel X, Forcade E, Batard S, Devillier R, Gonzague-Casabianca L, Chevallier P, Guimas V, Brissot E, Maertens J, Poiré X, Ceballos P, Llorente CC, Bilger K, Bulabois CE, Cherif AM, Coraggio G, Quoc SN, Robin M, Loganadane G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41135711

Résumé

Total body irradiation (TBI) has been considered the myeloablative standard for fit adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). However, the only randomized phase III recently reported no benefit of TBI in adult patients. This report aims to investigate the role of TBI in patients from a large European database.