DNA methylation profiles and cancer in children conceived after assisted reproductive technology.

Fiche publication

Date publication

octobre 2025

Journal

Clinical epigenetics

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CALLANAN Mary

Tous les auteurs :
Ducreux B, Firmin J, Ferreux L, Patrat C, Clavel J, Ghantous A, Herceg Z, Callanan M, Fauque P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41121288

Résumé

Epidemiological studies have shown a small but significantly increased risk of leukemia in children conceived by in vitro fertilization. Atypical DNA methylation patterns observed in pediatric cancers are suspected to occur in utero, and it is known that periconceptional conditions linked to assisted reproductive technologies (ART) are responsible for DNA methylation modifications.