Effect of Breast Surgery on Quality of Life in BRCA Mutation Carriers With Invasive Breast Cancer: A CANTO Database Study.

Date publication

septembre 2025

Journal

Clinical breast cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BERTAUT Aurélie , Pr COUTANT Charles , Pr PETIT Thierry

Tous les auteurs :
Mahiou K, Bonneau C, Coutant C, Martin AL, Gaudin C, Fournier M, Jacot W, Kieffer A, Sauterey B, Tredan O, Campone M, Tarpin C, Lerebours F, Mouret-Reynier MA, Petit T, Guillermet S, Constantin G, Bertaut A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41046190

Résumé

Breast cancer affects over 61,000 women annually in France. While only 5-10% of breast cancers are hereditary, BRCA1/2 mutations significantly increase the lifetime risk of breast and ovarian cancer, with cumulative invasive breast cancer risks of 72% (BRCA1) and 69% (BRCA2) by age 80. Surgical management in this population is crucial, as it directly impacts quality of life (QoL). However, prospective comparative data on surgical strategies are lacking.

Mots clés

BRCA mutations, Hereditary breast cancer, Quality of life, Surgical management, Survivorship

Référence

Clin Breast Cancer. 2025 09 4;: