Interference of therapeutic monoclonal antibodies with electrophoresis and immunofixation of serum proteins: state of knowledge and systematic review.

Fiche publication

Date publication

septembre 2025

Journal

Clinical chemistry and laboratory medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe , Dr OUDART Jean-Baptiste

Tous les auteurs :
Pelletier S, Florent L, Gillery P, Oudart JB

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40884068

Résumé

The increasing use of therapeutic monoclonal antibodies (t-mAbs) has improved cancer and autoimmune disorder treatment. These therapeutics can interfere with serum protein electrophoresis (SPEP) and immunofixation (IF), potentially leading to the appearance of monoclonal bands that may be misinterpreted as monoclonal gammopathies. Identifying the migration patterns and detection thresholds of t-mAbs is crucial to avoid misinterpretation in clinical laboratories.