Extensive cerebral white matter involvement in a patient with NMO spectrum disorder.

Date publication

septembre 2014

Journal

Multiple sclerosis (Houndmills, Basingstoke, England)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme

Tous les auteurs :
Ayrignac X, Dalière CC, Nerrant E, Vincent T, De Seze J, Labauge P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/24852925

Résumé

Abnormal brain MRI has been described in up to 60% of patients with NMO patients. However, white matter T2 hyperintensities have been rarely observed. We report the case of a 49-year-old woman with long-lasting neuromyelitis optica (NMO) spectrum disorder and diffuse cerebral white matter T2-weighted hyperintensities. Our case suggests that some NMO patients can progressively develop l extensive cerebral involvement.

Mots clés

Aquaporin 4, immunology, Autoantibodies, blood, Biomarkers, blood, Disease Progression, Female, Humans, Immunosuppressive Agents, therapeutic use, Leukoencephalopathies, diagnosis, Magnetic Resonance Imaging, Middle Aged, Neuromyelitis Optica, blood, Predictive Value of Tests, Time Factors, Treatment Outcome, White Matter, pathology

Référence

Mult. Scler.. 2014 Sep;20(10):1401-3