Retrospective Multicentre Real-Life Study Evaluating the Efficacy of Atezolizumab Combined with Bevacizumab for the Treatment of Metastatic Hepatocellular Carcinoma: HIREAL Study.

Fiche publication

Date publication

juillet 2025

Journal

Journal of hepatocellular carcinoma

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BELLETIER Christine , Dr BEN ABDELGHANI Meher

Tous les auteurs :
Barbe-Richaud JB, Moinard-Butot F, Husson-Wetzel S, Bolliet M, Chiappa P, Belletier C, Ribeiro M, Poprawa E, Bigot C, Abergel A, Ben Abdelghani M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40620668

Résumé

Hepatocellular carcinoma (HCC) is the most common hepatic malignancy and is one of the most prevalent cancers worldwide. The prognosis of late-stage HCC remains poor. The ImBrave 150 trial successfully demonstrated that overall survival (OS) and progression-free survival (PFS) was improved among patients treated with atezolizumab combined with bevacizumab (AB) compared with patients treated with sorafenib. Real-world data are essential to assess the safety and efficacy of new therapies in HCC, given patients' fragility and the heterogeneity of underlying liver diseases.