Fiche publication
Date publication
août 2025
Journal
Journal of hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
,
Dr CROUCHET Emilie
Tous les auteurs :
Del Zompo F, Crouchet E, Ostyn T, Nehme Z, Messé M, Juehling F, Désert R, Vieira AT, Moehlin J, Nakib D, Andrews T, Perciani C, Chung S, Bader G, McGilvray I, Caime C, Scaravaglio M, Carbone M, Invernizzi P, Yaqub S, Folseraas T, Karlsen TH, Shankar G, Primeaux M, Dhawan P, Banales JM, Roehlen N, Iacone R, Teixeira G, Heikenwälder M, Mailly L, MacParland S, Roskams T, Govaere O, Schuster C, Baumert TF
Lien Pubmed
Résumé
Primary sclerosing cholangitis (PSC) is a cholangiopathy associated with high risk of development into end-stage liver disease and hepatobiliary cancer. The pathogenesis is poorly understood, and current clinical care offers limited therapeutic options, primarily relying on liver transplantation. Claudin-1 (CLDN1), a transmembrane protein highly expressed in liver epithelial cells, plays a crucial role in cell-cell communication and signaling. Here we aimed to investigate the functional role of CLDN1 as a mediator and therapeutic target for PSC using patient cohorts combined with murine and patient-derived intervention models.
Mots clés
antibody therapy, biliary fibrosis, cholangiopathies, proof-of-concept, signaling
Référence
J Hepatol. 2025 08 20;:
