Spatiotemporal analysis of Crohn's disease reveals PECAM2 signaling at the basis of inflammation-to-fibrosis transition.

Fiche publication

Date publication

juillet 2025

Journal

Journal of Crohn's & colitis

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent

Tous les auteurs :
Massimino L, Parigi TL, Riva M, Nicolò S, Errico C, Spanò S, Mino S, Bugatti M, Frontali A, Scarfò F, Vignali A, Municchi A, Villanacci V, Albarello L, Ponzoni M, Solitano V, Malesci A, Jairath V, Peyrin-Biroulet L, Sileri P, Danese S, Ungaro F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40680170

Résumé

Crohn's disease is a chronic inflammatory disease of the bowel, often complicated by fibrotic strictures, for which medical treatment is lacking, and surgery is commonly required. The mechanisms underlying the progression from chronic inflammation to fibrosis are not yet defined. We aim to unravel Crohn's disease pathogenesis using a cutting-edge computational pipeline combining several available tools.