Atezolizumab and bevacizumab, with or without radiotherapy, versus docetaxel in patients with metastatic non-small cell lung cancer previously treated with a checkpoint inhibitor and chemotherapy: results from the randomized, phase Ib/II MORPHEUS-Lung stu

Fiche publication

Date publication

août 2025

Journal

Journal for immunotherapy of cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François

Tous les auteurs :
Ghiringhelli F, Lawrence YR, Felip E, Zer A, Greillier L, Greystoke A, Pardo N, Al-Sakaff N, Helms HJ, Prizant H, Pintoffl J, Lim FL, Lim SM, Cho BC

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40759444

Résumé

Options remain limited for patients requiring later lines of therapy for metastatic non-small cell lung cancer (mNSCLC) due to poor prognosis and potential toxicities. Therefore, trials of novel combinations of existing therapeutic candidates are warranted. Here, we report robust interim analysis results from the MORPHEUS-Lung study in immune checkpoint inhibitor (CPI)-exposed patients with non-squamous mNSCLC and without targetable gene mutations.