Fiche publication
Date publication
août 2025
Journal
British journal of anaesthesia
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARROT Michel
Tous les auteurs :
Attal N, Barrot M
Lien Pubmed
Résumé
The opioid crisis has prompted an urgent search for nonopioid analgesics for both acute and chronic pain. Among these, sodium channel antagonists, particularly those targeting Na1.7 and Na1.8, have emerged as potential pain management solutions. Recent large trials have shown some efficacy of the new Na1.8 allosteric inhibitor suzetrigine in acute postoperative pain, and ongoing studies are investigating its potential for painful diabetic neuropathy. If efficacy is confirmed, this type of drug might fill a significant gap in the treatment of acute and chronic pain, offering a safer alternative to opioids and marking the advent of a new class of nonopioid analgesics.
Mots clés
Nav1.8, acute postoperative pain, analgesics, neuropathic pain, nonopioid analgesics, sodium channels, suzetrigine
Référence
Br J Anaesth. 2025 08 11;:
