Fiche publication
Date publication
avril 2025
Journal
Frontiers in bioengineering and biotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr OLMOS Eric
Tous les auteurs :
Dauphin T, de Beaurepaire L, Salama A, Pruvost Q, Claire C, Haurogné K, Sourice S, Dupont A, Bach JM, Hervé J, Olmos E, Bosch S, Lieubeau B, Mosser M
Lien Pubmed
Résumé
Small extracellular vesicle (sEV)-based therapies have gained widespread interest, but challenges persist to ensure standardization and high-scale production. Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.
Mots clés
bioprocess, bioproduction, bioreactor, extracellular vesicles, scale-up, shear stress, spheroid
Référence
Front Bioeng Biotechnol. 2025 04 29;13:1516482
