Fiche publication
Date publication
mai 2025
Journal
Stem cell research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CALLIER Patrick
Tous les auteurs :
Desprat R, Magnano M, Bensadoun P, Soubeyrand M, Callier P, Alle Q, Bailly A, Gantenbein B, Laagland LT, Tryfonidou M, Guicheux J, Camus A, Milhavet O, Lemaitre JM
Lien Pubmed
Résumé
Notocordal-like cells (NLCs) produced from hiPSCs is considered as a promising candidate for cell-based regenerative therapies to treat intervertebral disk degeneration (IVDD). However, OCT4, SOX2, KLF4, C-MYC (OSKM) reprogramming into iPSC was described to maintain (epi)genomic hallmarks of the origin tissue impacting differentiation abilities. In this context, we produced a three donors-derived unique collection of hiPSCs reprogrammed with OSKM, from two cell types, PBMC and Tie2+ nucleus pulposus-progenitor cells (NPPCs). This collection will allow to further evaluate whether the production of NLCs from iPSCs derived from NPPCs or from PBMC would be the most relevant strategy for hiPSC-based IVDD therapy.
Référence
Stem Cell Res. 2025 05 16;86:103736
