Fiche publication
Date publication
mai 2025
Journal
Journal of molecular biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SEXTON Thomas
Tous les auteurs :
Nazarova M, Sexton T
Lien Pubmed
Résumé
Gene regulation involves a dynamic and precise choreography, with enhancers and promoters moving through the nuclear landscape in search of functional encounters. Advances in live-cell imaging have revealed that they do not follow universal rules, but instead explore their environment with peculiar specificity. Yet we are still far from understanding how this motion translates into transcriptional output. How do enhancers find and activate their target genes? Are these processes coordinated or independent? This review studies the evolving view of enhancer-promoter dynamics, focusing on the insights from cutting-edge imaging techniques and the challenges of capturing their fleeting movements in real time.
Mots clés
Chromatin dynamics, Chromatin organization, Enhancers, Transcription
Référence
J Mol Biol. 2025 05 20;:169223
