A Biodegradable 2D Metallic MoS Genesheet for Synergistic NIR-II Photothermal Immunotherapy.

Fiche publication

Date publication

juin 2025

Journal

Small (Weinheim an der Bergstrasse, Germany)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BIANCO Alberto

Tous les auteurs :
Zhu L, Xu J, Ren J, Yang M, Yang C, Gao X, Bianco A, Ji DK

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40457643

Résumé

Developing promising biodegradable second near-infrared (NIR-II) immune agonists to overcome the insufficient immunogenicity of tumor cells and the poor immune response remains challenging. In this work, a biodegradable "2D genesheet" is explored for synergistic NIR-II photothermal immunotherapy. The 2D genesheet is large-scale prepared through flexible supramolecular self-assembly between metallic-MoS and siRNA. The 2D genesheet not only exhibits an excellent photothermal conversion efficiency up to 56% in the NIR-II window, but also features unique HO-responsive biodegradability and high biocompatibility. The 2D genesheet can efficiently deliver siRNA(siIDO) to tumor cells and downregulate indoleamine 2,3-dioxygenase 1 (IDO1) protein expression, exerting intrinsic immune activation and reversing IDO1-mediated immunosuppression. The spatiotemporal-controlled NIR-II phototherapy can elicit systemic immunity by evoking immunogenic cell death, promoting dendritic cell maturation, and increasing T cell infiltration. The bioactive material is able to efficiently inhibit primary and distant tumors, achieving a 100% tumor eradication rate. This study broadens the application prospects of biodegradable NIR-II immune agonists, overcoming the limitations of current immunotherapeutic modalities.