Retrospective comprehensive analysis of regional lymph node recurrence in breast cancer patients (REASON study).

Fiche publication

Date publication

mai 2025

Journal

Journal of cancer research and clinical oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CURTIT Elsa

Tous les auteurs :
Liapi A, Aedo-Lopez V, Jeanneret-Sozzi W, Stravodimou A, Prior JO, Lalonde MN, Treboux AI, Lelievre L, Kandalaft L, Rossier L, Goupil A, Bergomi M, Rivals JP, Brouland JP, Curtit E, Meuwly JY, Zaman K

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40439756

Résumé

Randomized trials have progressively enabled the de-escalation of axillary surgery in breast cancer (BC) patients, reducing adverse events without compromising survival. Despite a not negligible rate of residual disease in the axilla after sentinel lymph node (SLN) procedure, the risk of regional lymph node recurrence (RLNR) is very low, due probably to multimodal adjuvant treatments. The characteristics of the small number of patients with RLNR remain poorly characterized and warrant further investigation, especially given their poor prognosis and the current context of ongoing studies exploring further de-escalation of axillary surgery.