Fiche publication
Date publication
mai 2025
Journal
The New England journal of medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GIRODON François
Tous les auteurs :
Martin L, Maric D, Idriss S, Delamare M, Le Roy A, Maaziz N, Caillaud A, Si-Tayeb K, Robriquet F, Lenglet M, Erceau L, Bellanné-Chantelot C, Plo I, Aral B, Garrec C, Airaud F, Gianfermi C, Antunes V, Keppner A, Vincent SM, Desfontaine A, Modé N, Laporte F, Gaignerie A, Chariau C, Leray I, Rogue C, David L, Redon R, Bézieau S, Mansour-Hendili L, Galactéros F, Maillet T, Pasquet M, Cougoul P, Nloga AM, Gardin C, Guitton C, Dubruille V, Giacobbi-Milet V, Leblanc T, Kaya Z, Semama D, James C, Carillo S, Ochmann M, Waage A, Mortier E, Maillasson M, Quéméner A, Cario H, Skoda RC, Zermati Y, Hoogewijs D, Marchand A, Girodon F, Gardie B
Lien Pubmed
Résumé
Secondary erythrocytosis often results from conditions that cause tissue hypoxia or an improper increase in erythropoietin (EPO) production. EPO, the major regulator of erythropoiesis, has a complex and tightly regulated expression during development, with a liver-to-kidney switch shortly after birth.
Mots clés
Humans, Polycythemia, genetics, Erythropoietin, genetics, Male, Female, Infant, Newborn, Induced Pluripotent Stem Cells, Hepatocytes, metabolism, Liver, metabolism, Adult, Pedigree, Mutation
Référence
N Engl J Med. 2025 05 1;392(17):1684-1697
