Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice.

Date publication

avril 2025

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MASSON David

Tous les auteurs :
Pilot T, Solier S, Jalil A, Magnani C, Vanden Berghe T, Vandenabeele P, Masson D, Solary E, Thomas C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40264785

Résumé

Cell death plays a central role in atheroma plaque progression and aggravation. This study investigates the role of caspase-8 in regulating macrophage cell death modalities, specifically apoptosis and necroptosis, within atheroma plaques.

Mots clés

apoptosis, atherosclerosis, caspase-8, macrophages, necroptosis, necrotic core

Référence

Front Immunol. 2025 04 8;16:1513637